Diseases

Idiopathic inflammatory myositis (IIM) is a chronic rheumatic muscle disease, which can be subdivided into polymyositis, dermatomyositis and inclusion body myositis. The etiology of the disease is largely unknown. IIM results in skeletal muscle weakness and pain, and muscles are infiltrated with cytotoxic T cells and macrophages. Other organs beside skeletal muscle are in some cases involved, such as inflammation in lungs,…

Systemic Lupus Erythematosus (SLE) is a systemic inflammatory autoimmune disease affecting many organs of the body, such as skin, joints and kidney. It is a markedly heterogenic disease with different sets of symptoms in different patients, and with periods of flares and quiescence. The etiology of the disease is unknown, but genetic as well as environmental factors play a role. SLE patients are often treated with corticosteroids and other antiinflammatory agents, and…

Ankylosing spondylitis (AS) is an inflammatory arthritis of the axial skeleton that predominantly affects young men. Although primarily affecting the spine, other joints can become involved. It causes inflammation of the vertebrae that can lead to severe pain and discomfort. In more advanced cases this inflammation can lead to ankylosis - new bone formation in the spine causing sections of the spine to fuse in a fixed, immobile position. AS can also affect other areas of the body such as the…