Unrestricted Leveraging of Targets for Research Advancement and Drug Discovery

Our aim is to identify and validate under-explored novel targets in auto-immune and inflammatory diseases. We do this by creating and profiling target-directed chemical and antibody probes in the highest quality patient-cell derived assays, providing biomarker and phenotypic read-outs in a more disease relevant context.

  • Generate protein based research tools (e.g. structures, assays)
  • Generate chemical and antibody probes
  • Use patient-cell derived assays for target definition and validation
  • Make all reagents and knowledge available through Open Source
  • Significantly contribute to understanding of complex disease systems
  • Promote drug discovery and development
  • Fibrosis (of e.g. hand, lung and liver)
  • Ankylosing spondylitis (AS)
  • Fibrodysplasia ossificans progressiva (FOP, stone man syndrome)
  • Systemic Lupus Erythematosus (SLE)
  • Idiopathic myositis
  • Systemic sclerosis (SSc)
  • Sjogren´s syndrome (SS)